Aishwarya Venugopal

This study shows that OCRL regulates lysosomal function and endolysosomal homeostasis in Drosophila nephrocytes by affecting PI(4,5)P2 homeostasis.

The paper shows that PIP4K regulates PI(3,4)P2 levels in Drosophila salivary gland cells through Class II PI3K activity, not directly via its catalytic function.

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.