Nicole Jane Francis

The paper shows that TDP-43 pathology causes a cryptic exon in G3BP1 to be included in neurons, leading to a protein that disrupts stress granule dynamics in ALS/FTD.

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

This study reveals a two-step mechanism by which the PRC1 complex creates stable chromatin condensates through phase separation and chromatin bridging.

The paper identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites through passive demethylation during replication.