Tien Minh Phan

This study shows that scaffold binding affinity determines condensate phase behavior, dynamics, and biochemical output in vitro and in human cells.

This study investigates how electrostatic interactions influence HP1α phase separation and its interactions with binding partners, showing that these interactions modulate HP1's properties and functions.

This study uses multiscale simulations to investigate polyglutamine aggregation mechanisms and how the N17 flanking domain influences fibril polymorphism in Huntingtons disease.

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

This study investigates the molecular interactions driving phase separation in MBD2 and MBD3 proteins, revealing distinct mechanisms despite their structural similarity.

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

This paper characterizes the structure and dynamics of HSPB1 oligomers using biophysical and computational methods, revealing conformational heterogeneity and domain-specific interactions.