David VanInsberghe

The paper investigates how spatial expansion and dispersal modulators affect viral population structure and genetic diversity during infection.

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

This study compares sfRNA secondary structure dynamics in vitro and in infected cells across multiple flaviviruses, identifying conserved and variable structural features.

This study identifies a conserved SARS-CoV-2 5-UTR stem-loop region that activates OAS1, a key antiviral protein, through structural and functional analyses.

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

This study shows that influenza A virus lineage and exposure route affect its spatial distribution and genetic diversity within the respiratory tract of guinea pigs.

This study investigates how viral aggregation affects infection dynamics and genetic diversity in mammalian orthoreovirus, finding that it reduces replicative potential but increases evolutionary potential through reassortment.

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

This study identifies viral expansion after transfer as a key factor in influenza A virus transmission bottlenecks, showing that diversity declines rapidly post-infection.

This paper introduces a topological data analysis framework to model microbiome dynamics, identifying state transitions linked to health and environmental processes.