Valerie Le Sage

This study analyzes an H5N5 influenza virus isolate that caused a human fatality, finding it lacks key traits associated with human pandemic potential.

The paper identifies a disrupted CCR5-like immunoglobulin gene in black-footed ferrets linked to increased susceptibility to plague caused by Yersinia pestis.

This study evaluates a novel TLR4 adjuvant, BECC470s, in enhancing rHA vaccination against H5N1 influenza in mice, showing improved antibody responses but limited cross-neutralizing activity.

The paper assesses transmission efficiency of D1.1 H5N1 strains in ferrets, finding only one human isolate efficiently transmits, linked to the PB2 D701N mutation.

The study assesses the pandemic risk of a fatal zoonotic H3N8 influenza virus from chickens, finding it has moderate pandemic potential due to its ability to infect humans and replicate in human cells.

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

This study identifies human antibodies that broadly inhibit influenza neuraminidase by mimicking its substrate through structural convergence and water-mediated interactions.

The paper develops a replicating recombinant vesicular stomatitis virus expressing H5N1 influenza glycoproteins to study viral resistance and antibody escape without biocontainment constraints.

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

This study shows that pre-existing H1N1 immunity protects ferrets from severe disease caused by bovine H5N1 influenza virus.

This paper identifies phosphorylation sites in HSV-2 pUL21 and shows that phosphorylation is required for secondary envelopment of nucleocapsids and virus replication.

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

This study shows that influenza-infected macrophages release viral ribonucleoproteins (vRNPs) that trigger inflammatory responses in uninfected cells through the RIG-I/MDA5 pathway.