Anice C. Lowen

The paper investigates how spatial expansion and dispersal modulators affect viral population structure and genetic diversity during infection.

This study compares antibody responses in infants after influenza infection or vaccination, finding greater post-exposure responses following infection compared to vaccination.

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

This study compares sfRNA secondary structure dynamics in vitro and in infected cells across multiple flaviviruses, identifying conserved and variable structural features.

This study identifies a conserved SARS-CoV-2 5-UTR stem-loop region that activates OAS1, a key antiviral protein, through structural and functional analyses.

This study shows environmental stochasticity can explain within-host viral evolution patterns without needing demographic stochasticity or constant population size assumptions.

The paper develops chicken lung organoids to model avian influenza virus-host interactions and finds they contain diverse cell types and express relevant viral infection genes.

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

This paper develops a framework to estimate pandemic potential from experimental transmission studies by analyzing within-host viral dynamics and extrapolating to epidemiological parameters.

This study shows that influenza A virus lineage and exposure route affect its spatial distribution and genetic diversity within the respiratory tract of guinea pigs.

This study investigates how viral aggregation affects infection dynamics and genetic diversity in mammalian orthoreovirus, finding that it reduces replicative potential but increases evolutionary potential through reassortment.

This study identifies viral expansion after transfer as a key factor in influenza A virus transmission bottlenecks, showing that diversity declines rapidly post-infection.

This study uses a murine menstruation model to show that NK cell infiltration during endometrial remodeling protects against Chlamydia muridarum infection.

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.

This study shows that ventilation rates do not affect influenza virus transmission efficiency in a ferret playpen setup with close-range interactions and fomites.

This study examines within-host influenza A virus diversity and evolution in swine, finding low genetic diversity and evidence of purifying selection and genetic drift.