Alexandra V. Bruter

This study identifies that acute myeloid leukemia (AML) sensitivity to CDK8/19 inhibitors is linked to their metabolic profile, specifically glycolytic activity and TCA disruption.

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

This study shows that CDK8/19 inhibition overcomes BCR-ABL inhibitor-induced G1 arrest and promotes apoptosis in CML cells.

This study shows that the Eg5 inhibitor SB743921 induces p53-dependent cell cycle arrest, senescence, and death in tumor cells, particularly in TP53-mutated cells, with potential for combinational therapy with senolytic drugs.