Author

Igor B. Roninson

University of South CarolinaORCID 0000-0002-9211-1327Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Mengqian CheniD· 3 shared Eugenia V. BroudeiD· 2 shared Abhyudai SinghiD· 1 shared Alexander Albertovich ShtiliD· 1 shared Alexandra V. BruteriD· 1 shared Alexey V. FeoktistoviD· 1 shared Alissa Richmond ArmstrongiD· 1 shared Alvina I. KhamidullinaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

Mengqian ChenORCID

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3 papers

Recent·Most cited

Cancer Biologynpj Breast CancerPeer-reviewedJan 17, 2026

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson…·Hexin Chen

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

6 citationstop 2%

mousebulk RNA-seq

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Cancer BiologyJCI InsightPeer-reviewedJan 15, 2026

Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 Mediator kinase inhibition.

Mehri Monavarian, Resha Rajkarnikar, Emily Faith Page…·Karthikeyan Mythreye

This study shows CDK8/19 inhibition can reverse anoikis resistance and metastasis in ovarian cancer by altering transcriptional programs.

5 citationstop 1%

humanbulk RNA-seq

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Developmental BiologyeLifePeer-reviewedApr 2, 2025

Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya…·Victor Vyacheslavovich Tatarskiy

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

8 citations

mousebulk RNA-seq

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