Guoliang Yin

The paper identifies TRiC/CCT as a chaperonin in mammalian sperm flagella that folds locally translated proteins, supporting flagellar function and fertility.

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

This study shows that CFAP77 is essential for connecting axonemal A and B tubules in mammalian sperm, as its loss disrupts the CFAP77-CCDC105-TEX43 complex and impairs sperm motility.

This study identifies ANKRD5 as a critical component of the N-DRC in sperm axonemes, showing its role in maintaining structural integrity and motility, with implications for male fertility.

The paper solves the in-cell structure of mouse sperm central apparatus at sub-nanometer resolution and identifies proteins critical for its asymmetric assembly.

The paper determines the architecture of the nuclear ring in Xenopus laevis NPC using cryo-EM, homology modeling, and cell experiments, identifying key proteins and their roles in NPC assembly.