Jeffrey E. Lee

This paper develops a JUNO-coated bead assay to capture and characterize fertilization-competent human sperm, showing that vitrification preserves functional binding while slow freezing increases non-specific interactions.

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

The paper determines the structure of SPACA6, a sperm protein critical for gamete fusion, and identifies it as a founding member of a conserved superfamily of gamete fusion-associated proteins.