Cell BiologyCommunications BiologyPeer-reviewed
GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium
Jessica K. Bruce, L Y Li, Yu Tang…·Stephen E. Girardin
This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.