Daisuke Ogasawara

This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.

The paper identifies IPO9 as a regulator of cGAS-STING signaling by releasing cGAS from H2A-H2B dimer inhibition, revealing structural insights into this mechanism.

This study identifies erucamide as a key regulator of retinal neurovascular crosstalk, showing its role in stabilizing retinal degeneration through TMEM19-mediated activation of myeloid cells.

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

The paper uses base editing to assess the functional impact of cysteine mutations in cancer dependency genes, identifying essential and ligandable cysteines for drug development.