Shaunna R. Simmons

This study identifies CD73 as a regulator of neutrophil responsiveness to type I interferon, which impairs antibacterial responses during secondary pneumococcal pneumonia following influenza A virus infection.

This study shows that aged neutrophils have impaired antimicrobial activity against antibody-opsonized pneumococci due to imbalanced ERK1/2 activation, which can be improved by ERK1/2 inhibition.

This study shows that adenosine 2B receptor signaling impairs neutrophil killing of antibody-opsonized pneumococci in young vaccinated mice, reducing vaccine efficacy, but not in aged mice.

This study shows that activating A1 adenosine receptors in aged mice enhances early neutrophil recruitment to the lungs during Streptococcus pneumoniae infection, improving bacterial control.