Daniel D. Billadeau

The paper shows T cells can kill target cells via TNF and IFNγ in a paracrine, perforin-independent manner, with pathogen-derived factors enabling selective elimination of infected cells.

This study identifies PD-1's role in regulating effector potential and exhaustion in thymic CD8+ T cells, showing that PD-1 inhibition enhances expansion but leads to exhaustion in tumor tissues.

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.