Hu Zeng

This study shows ACLY links metabolism to chromatin accessibility in B cells, essential for activation and humoral immunity.

Immunopipe provides a flexible pipeline for integrated analysis of scRNA-seq and scTCR-seq data to enhance understanding of T-cell immunity and immunotherapy.

This study investigates the role of mTORC2 in SLE and shows that targeting mTORC2 reduces immunopathology in both mouse models and human PBMCs.

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

This study shows that CPT2-mediated fatty acid oxidation is not essential for humoral immunity in mice, as CPT2 deficiency does not impair B cell development, activation, or antibody production.

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.