Author

Sudha B. Biddinger

Boston Children's HospitalORCID 0000-0002-2352-067XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Bandana SinghiD· 2 shared Beibei WangiD· 2 shared Douglas B. CowaniD· 2 shared Hong CheniD· 2 shared Kaifu CheniD· 2 shared Kathryn S. Li· 2 shared Kui CuiiD· 2 shared Marina V. MalovichkoiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Bandana SinghORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologyMolecular MetabolismPeer-reviewedJul 16, 2025

The Diabetes Gene Tcf7l2 Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism

Joanna Krawczyk, William O’Connor, Pedro Henrique Vendramini…·Sudha B. Biddinger

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

3 citations

mousemetabolomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 26, 2024

Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor Degradation

Bo Zhu, Krishan Gupta, Kui Cui…·Hong Chen

This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.

4 citations

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintDec 4, 2023

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

Hao Wu, Kui Cui, Bo Zhu…·Hong Chen

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

DOI 10.1101/2023.12.04.569948

mousebulk RNA-seq

𝕏 PostBluesky