Author
AstraZeneca (United Kingdom)ORCID 0000-0002-2363-3391Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Julia Y. Chu, Elpida Tsonou, Polly A. Machin…·Heidi C. E. Welch
This study shows Prex1 regulates glucose homeostasis by reducing glucose uptake and mitochondrial metabolism in the liver, independent of its catalytic activity, through Gpr21 inhibition.
Martin J. Baker, Elizabeth Hampson, Priota Islam…·Heidi C. E. Welch
This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.
Catriona A. Ford, Dana Koludrović, Patricia P. Centeno…·Andrew D. Campbell
This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.