Weiguo Fan

This study identifies HA and CD44 as mediators of matrix changes and fibrosis in PSC, showing their targeting can reverse disease progression.

This study identifies ECM1 as a gatekeeper that transiently suppresses HGF activity during liver regeneration, enabling tissue repair through c-MET-ERK-MYC signaling.

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.