Jeff S. Mumm

A zebrafish phenotypic drug screen identifies 49 ApoB-lowering compounds, with enoxolone showing efficacy dependent on HNF4 function, validating the LipoGlo platform for B-lp modulation.

The paper shows that cancer cells switch between glycolysis and oxidative phosphorylation based on microenvironment stiffness, affecting their migration patterns.

This paper develops threshold-free deep learning models for detecting swim bouts in larval zebrafish, showing improved precision over traditional methods and revealing behavioral patterns across genetic backgrounds.

This study develops a chemogenetic ablation model in zebrafish to study ENS neuron regeneration, showing complete restoration of most neuron subtypes but partial recovery of serotonergic neurons.

The paper develops fluorescently labeled split-QF and QF2 hemidrivers in zebrafish to simplify intersectional targeting and enable quality control of split-driver function.

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

This paper introduces a self-adaptive oblique plane microscopy technique that enables high-speed volumetric imaging across microscopic to macroscopic scales in multi-cellular systems.

This paper develops a zebrafish xenograft model for diffuse midline glioma by transplanting human DMG cells into zebrafish embryos to enable high-throughput drug screening.

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

The paper compares transcriptomic responses in zebrafish following rod photoreceptor or bipolar cell loss, identifying cell-specific and shared regenerative gene programs and immune-related regulators.

The paper shows motor asymmetry in larval teleosts is conserved across species and driven by thalamic neurons, with forms dependent on vision and independent of it.

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.

This study shows that dendrimer-targeted immunosuppression of microglia accelerates photoreceptor regeneration in zebrafish retinas.