Lizhou Zhang

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

The paper identifies variation in virion phosphatidylserine content as the reason for differential GAS6 binding among flaviviruses, explaining ZIKV's unique ability to use AXL for entry.

This study compares the functional differences between human, rhesus, and mouse TIM1 proteins, showing that human TIM1's ability to bind phosphatidylethanolamine enhances viral uptake and efferocytosis compared to its orthologs.

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.