Mimi Shirasu‐Hiza

This study identifies impaired glial-mediated synaptic refinement in FXS model mice, showing enhanced astrocyte-microglia signaling and synaptic over-engulfment as key features.

This study identifies germ lineage-specific DAF-16 patterning and a role for DAF-16 in early embryogenesis independent of canonical DAF-2 signaling.

This study shows that time-restricted eating in Drosophila leads to sustained fat loss and improved muscle function without calorie restriction.

This study shows that evolving the Drosophila gut microbiome to resist oxidative stress improves host health and extends lifespan.

This study investigates how chronic short sleep affects metabolism and survival under oxidative stress in mutants, finding common metabolic defects and suggesting lipid metabolism issues may underlie oxidative stress sensitivity.

The paper identifies cell type-specific differences in cytokinesis regulation in C. elegans embryos using temperature-sensitive mutants.

This study investigates the spatial and temporal dynamics of FoxO/DAF-16 in C. elegans embryos and its role in cell cycle regulation during early development.

The paper identifies PIE-1 and POS-1 as germ fate determinants that protect P2 germ precursor cells from cytokinesis failure by reducing septin and anillin levels at the division plane.

The paper uses CRISPR to disrupt clock genes in specific Drosophila neurons, showing that neither the morning nor evening oscillator alone is sufficient for circadian locomotor activity, indicating a distributed network function.

The paper develops a k-nearest neighbors classifier to analyze grooming behavior in Drosophila, revealing two internal programs controlling grooming timing and duration.