Qionghua Shen

This study maps how distinct oncogenic drivers induce unique multiscale architectural changes in liver tissue, revealing mutation-specific remodeling across cellular and mitochondrial structures.

Altair-dvOPM is an open-access microscope for large-field 3D tissue imaging, achieving micrometer resolution without custom objectives or specialized alignment.

This paper introduces Cy-ExM, a high-plex imaging strategy that enables 3D super-resolution mapping of cellular ultrastructure in mammalian cells.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

The paper introduces MCT-ASLM, a microscopy platform that enables subcellular resolution imaging of whole tissues, demonstrating its application in studying neuronal circuits, kidney innervation, and tumor microenvironments.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

The paper introduces a new image acquisition method for light-sheet microscopes that improves spatial context placement and reduces post-processing needs, achieving higher field of view and resolution.

The paper identifies GvpU as the protein governing gas vesicle clustering and shows how its phase transition behavior modulates cellular fitness and clustering states.

This paper introduces 50-nm gas-filled protein nanostructures that can traverse biological barriers and access lymphatic cells via ultrasound technologies.