Bo-Jui Chang

This study maps how distinct oncogenic drivers induce unique multiscale architectural changes in liver tissue, revealing mutation-specific remodeling across cellular and mitochondrial structures.

This study shows that branched actin-driven membrane protrusions (BAMPs) enhance oncogenic KRAS signaling by amplifying upstream regulators and promoting cell proliferation through merlin inactivation.

This paper introduces Cy-ExM, a high-plex imaging strategy that enables 3D super-resolution mapping of cellular ultrastructure in mammalian cells.

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

This study identifies Caveolin-1 as a context-dependent regulator of survival signaling in Ewing Sarcoma, revealing a reversible CD99High state with enhanced survival.

The paper introduces u-Unwrap3D to map 3D cell surfaces and analyze interactions between geometry and molecular signals, revealing new dynamics in immune and tumor cell behaviors.

This paper introduces ctASLM, a light-sheet microscopy technique with sub-micron isotropic resolution and large-scale imaging, enabling automated cell and subcellular feature detection in cleared tissues.