Author

Hélène Malet

Centre National de la Recherche ScientifiqueORCID 0000-0002-2834-7386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:rat· 1 Organism:virus· 1

Frequent Co-Authors

Quentin Durieux TrouilletoniD· 2 shared Benoît ArragainiD· 1 shared Bert VanmecheleniD· 1 shared Birgit WeynandiD· 1 shared Claire DebarnotiD· 1 shared Concetta CastillettiiD· 1 shared Dietmar Rudolf ThaliD· 1 shared Dominique HoussetiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Quentin Durieux TrouilletonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 18, 2026

Hantaan virus polymerase has an in vitro Terminal Nucleotidyl Transferase activity that is conserved across the Bunyaviricetes class

Sergio Barata-García, Quentin Durieux Trouilleton, Claire Debarnot…·Juan Reguera

This study identifies terminal nucleotidyl transferase activity in Hantaan virus L protein and shows it is conserved across Bunyaviricetes class viruses.

DOI 10.64898/2026.09.16.751791

experimental assay

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MicrobiologybioRxivPreprintSep 22, 2025

4'-fluorouridine is a potent inhibitor of Oropouche virus in vitro and in animal infection models

Martin Ferrié, Maïlis Darmuzey, Itona Tarillon…·Johan H. Neyts

This study shows 4'-fluorouridine inhibits Oropouche virus replication in vitro and in animal models, with no resistant variants observed.

1 citation

mouserat

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BiochemistryNature CommunicationsPeer-reviewedMar 13, 2024

Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers

Quentin Durieux Trouilleton, Dominique Housset, Paco Tarillon…·Hélène Malet

This study characterizes the oligomerization of Hantaan virus polymerase into dimers and hexamers using cryo-EM, revealing structural changes upon RNA binding.

15 citations

cryo-EMexperimental assay

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