Steven Lynham

This study identifies POM121 as a regulator of lentiviral nuclear import, showing its effect is virus-specific and depends on capsid-host interactions.

The paper identifies differences in TDP-43 interactomes between the cortex and cerebellum in healthy mice, suggesting regional vulnerability to TDP-43 aggregation.

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

This study shows that tau aggregates from Alzheimer's disease brains are taken up and processed by human astrocytes, with differences in handling linked to astrocyte responses and gene expression changes.

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

This study shows that GSK3 and Lamellipodin regulate lamellipodia formation and focal adhesion maturation in mouse neural crest migration.

This study shows Sox9 regulates ECM stiffness and composition in vascular smooth muscle cells, promoting vascular ageing through a feedback loop between senescence and ECM changes.