Dan T. Vogl

This study shows mast cells enhance myeloma engraftment and promote bone destruction in the NSG-hIL6 xenograft model by secreting factors that improve myeloma cell survival.

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

This study shows that neutrophil extracellular traps (NETs) contribute to tumor resistance to anthracycline chemotherapy by binding the drugs and protecting cancer cells.

The paper establishes NSG+hIL6 mice as a model for studying multiple myeloma by showing they support engraftment of patient-derived myeloma cells and develop disease features.