David Allman

This study shows Notch2 signaling enhances TLR3 and TLR4 responsiveness in MZ B cells, promoting immune responses to viral and bacterial pathogens.

This study shows mast cells enhance myeloma engraftment and promote bone destruction in the NSG-hIL6 xenograft model by secreting factors that improve myeloma cell survival.

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

The paper establishes NSG+hIL6 mice as a model for studying multiple myeloma by showing they support engraftment of patient-derived myeloma cells and develop disease features.

This study shows that YY1 knockout in pro-B cells leads to lineage plasticity, enabling the generation of T lineage cells and revealing YY1's role in lineage commitment.

This study shows that increased IRE1 activity in a mouse model of EAE reduces inflammation and improves motor function, suggesting context-dependent protective effects of ER stress.