Author

Vennesa Valentine

Duke UniversityORCID 0000-0002-3331-3324Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Loren B. WeidenhammeriD· 2 shared Nerissa T. WilliamsiD· 2 shared Spencer M. Maingi· 2 shared Zachary J. ReitmaniD· 2 shared Adam GrothiD· 1 shared Avani MangoliiD· 1 shared Avneesh SaravanapavaniD· 1 shared Bronwen E. ForemaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Loren B. WeidenhammerORCID

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2 papers

Recent·Most cited

GeneticsNeuro-Oncology PediatricsPeer-reviewedMar 16, 2026

Oncogenic Ppm1d mutations deregulate the p53 pathway in primary mouse gliomas

Vennesa Valentine, Adam Groth, Joshua Tolliver…·Zachary J. Reitman

This study develops a mouse model of Ppm1d mutations in gliomas, showing they deregulate the p53 pathway, promote gliomagenesis, and increase radiosensitivity and PARP inhibitor vulnerability.

DOI 10.1093/neuped/wuag012

mousebulk RNA-seq

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Cancer BiologyJournal of Clinical InvestigationPeer-reviewedApr 17, 2025

Ataxia-telangiectasia mutated (Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

Avani Mangoli, Vennesa Valentine, Spencer M. Maingi…·Zachary J. Reitman

This study shows that disrupting ATM enhances radiation therapy efficacy in p53-mutant DMGs but not p53-wildtype DMGs using mouse models.

9 citations

mousespatial transcriptomics

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