Gülsün Elif Karagöz

This study shows that IRE1α assembly into filaments is dynamically regulated by unfolded proteins and BiP through opposing mechanisms.

This study shows IGF2BP3 regulates UPR effectors by stabilizing transcriptional regulators and destabilizing UPR target mRNAs during ER stress, modulating the UPR response.

This study uses molecular modeling and simulations to clarify how IRE1 detects unfolded proteins, revealing binding pockets and interactions that stabilize oligomers and prevent larger complex formation.

The paper identifies a retrograde signaling pathway where UFMylation of ER ribosomes anchors splicing factors at the ER, linking translational stress to nuclear RNA processing and altering membrane-associated gene expression.

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

This study identifies EDC4 and DCP1 as autophagy receptors for P-body turnover in Marchantia polymorpha, revealing lineage-specific adaptations and potential therapeutic applications.

The paper shows UFMylation and RQC work together to clear stalled ER-bound ribosomes and arrested nascent chains.

This study shows that phosphorylation of IGF2BP1 at S181 and Y396 modulates RNP condensate formation by altering low-affinity interactions with RNA and protein partners.