Subin S. George

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.

This study shows that PHF6 loss increases AML aggressiveness by enhancing leukemia stem cell self-renewal through context-specific transcriptional changes.

The paper customizes genome assemblies for rDNA mapping in human and mouse by masking repetitive regions and adding reference sequences, enabling better analysis of rDNA-binding factors.

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.