Brian Oliver

The paper screens for X-linked female sterile alleles using mdg4 retrotransposon insertions and finds that while mdg4 preferentially inserts near OVO binding sites, only a subset of sterile alleles result from this mechanism.

The paper identifies sex-specific allometric strategies in Drosophila organs, showing how cell size and number differ between sexes to drive body size differences.

This study identifies conserved molecular responses to arsenite exposure in Drosophila, revealing shared pathways with human arsenic-related diseases.

The paper investigates OVO's role in Drosophila female germline development, showing its continuous expression across generations and essential function in germ cell viability.

The paper investigates how somatic Transformer and sex chromosome karyotype pathways regulate gene expression during Drosophila gonad development, showing their combined and exclusive effects on germ cell development.

The paper identifies OVO as a master transcriptional regulator in Drosophila female germline development by showing it binds near TSSs of essential maternal genes and regulates their expression.

The paper provides single nucleus and single cell RNA-seq data from Drosophila testes to study spermatogenesis, identifying rare cell types and developmental transitions.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper shows that X and 4th chromosomes are inactivated while Y chromosomes are active in Drosophila primary spermatocytes using single-cell RNA-Seq.

This study shows that IRBIT suppresses RNR activity in intestinal stem cell progeny to drive differentiation into enterocytes, maintaining gut tissue integrity in Drosophila.

The paper introduces NetREX-CF, a method combining collaborative filtering and sparse network component analysis to reconstruct gene regulatory networks, outperforming existing methods.

The paper reannotates eight Drosophila genomes using a transcriptome assembly approach trained on Drosophila melanogaster, adding tens of thousands of new gene models and orthologs.

The paper investigates non-canonical dosage compensation on the Drosophila X chromosome, showing that repressive chromatin domains contribute to gene expression balance in males.

The paper introduces a high-throughput system for feeding, monitoring, and assaying Drosophila melanogaster adults using 96-well consumables.

This study identifies the small ovary (sov) gene in Drosophila, which encodes a zinc-finger protein required for ovarian differentiation by repressing cell signaling and transposons.

The paper investigates how gene copy number, dosage compensation, and expression noise interact in Drosophila, finding that one dose genes show higher expression variability and that dosage compensation increases noise in autosomal genes but not X-linked genes.

NetREX constructs context-specific regulatory networks by integrating expression data and context-agnostic networks, showing improved biological consistency in Drosophila data.

The paper examines gene dosage effects in Drosophila deficiency heterozygotes, finding varied transcriptional responses and minimal long-range regulatory impacts from breakpoints.