Author

Hyun-Kyung Chang

Columbia University Irving Medical CenterORCID 0000-0002-3490-7597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:DNA methylation· 1

Frequent Co-Authors

Adam D. HudginsiD· 2 shared Allen Y. ChungiD· 2 shared Di GuaniD· 2 shared Jiping YangiD· 2 shared Lauren E. FriesiD· 2 shared Robert C. BaueriD· 2 shared Xizhe Wang· 2 shared Yizhou ZhuiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Adam D. HudginsORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 5, 2026

Identification of functional non-coding variants affecting Alzheimer's disease risk by Massively Parallel Reporter Assay

Adam D. Hudgins, Hyun-Kyung Chang, Seung-Soo Kim…·Yousin Suh

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

DOI 10.64898/2026.04.30.721912

humanexperimental assay

𝕏 PostBluesky

PathologyJournal of Clinical InvestigationPeer-reviewedJan 29, 2026

ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis

Allen Y. Chung, Lauren E. Fries, Hyun-Kyung Chang…·Robert C. Bauer

This study identifies ADAMTS7's role in promoting atherosclerosis by enhancing smooth muscle cell foam cell formation via an AP-1/PU.1/CD36 pathway.

14 citationstop 1%

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GenomicsAtherosclerosisPeer-reviewedOct 3, 2025

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

Lauren E. Fries, Allen Y. Chung, Hyun-Kyung Chang…·Robert C. Bauer

The paper uses scRNA-seq to study adventitial fibroblast changes in mouse atherosclerosis and identifies SERPINH1 as a key regulator affecting fibroblast function.

3 citations

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GeneticsbioRxivPreprintMay 17, 2023

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

Jiping Yang, Archana Tare, Lei Justan Zhang…·Yousin Suh

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

1 citation

humanDNA methylation

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