Author

Mario A. Shields

Northwestern UniversityORCID 0000-0002-3562-9875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adrián Holguín-HorcajoiD· 1 shared Anastasia E. MetropulosiD· 1 shared Ben Z. StangeriD· 1 shared Christina SpauldingiD· 1 shared Davide BrusaiD· 1 shared Hidayatullah G. MunshiiD· 1 shared Ilianna ZoiiD· 1 shared Jane Xie· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adrián Holguín-HorcajoORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 7, 2025

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin

Ilianna Zoi, Memoona Rajput, Adrián Holguín-Horcajo…·Patrick Jacquemin

This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.

DOI 10.1101/2025.03.07.642043

mouseDNA methylation

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PathologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2024

BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss.

Mario A. Shields, Anastasia E. Metropulos, Christina Spaulding…·Hidayatullah G. Munshi

This study shows that BET inhibition rescues ciliogenesis and reduces pancreatitis-induced damage in mice with Par3 loss.

4 citations

mouseexperimental assay

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