Annemiek B. van Spriel

This study investigates how PD-L1 is organized into nanoscale clusters on tumor cell surfaces and identifies actin cytoskeleton, galectin-3, and cholesterol as key regulators of its spatial arrangement and function.

This study investigates how metabolic pathways influence cytokine production in diffuse large B-cell lymphoma, finding that glycolysis modulation affects IL-6, IL-10, and TNFα levels and that DLBCL subtypes respond differently to IL-4.

This study identifies TSPAN3 as a marker of a distinct secretory multivesicular body population with unique trafficking and EV composition compared to CD63-positive compartments.

This study shows that DuoHexaBody-CD37 induces direct cytotoxicity in DLBCL cells through CD37 clustering and signaling changes, independent of subtype.

This study shows CD82 reduces CADM1 oligomer formation by interacting with its extracellular domains, affecting transmembrane helix spacing and disrupting cell adhesion.

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

This study shows galectin-9 regulates dendritic cell migration by modulating RhoA activity and CD44-mediated rear contractility in both humans and mice.

The paper shows that combining three inhibitors represses B-cell signaling more effectively than single inhibitors in diffuse large B-cell lymphoma.