Guido van Mierlo

This study shows melanoma suppresses galectin-9 on dendritic cells, and restoring it limits T regulatory cell expansion, suggesting a new therapeutic target.

This study identifies TSPAN3 as a marker of a distinct secretory multivesicular body population with unique trafficking and EV composition compared to CD63-positive compartments.

This study identifies DNA binding motifs for 98 human transcription factors using meSMiLE-seq, revealing methylation-sensitive binding preferences for some TFs.

This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.

The paper introduces scTF-seq, a method to study TF dose-dependent reprogramming in mouse MSCs, revealing heterogeneity in cell fate and TF sensitivity.

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

The paper evaluates CM mapping tools, shows cell type-specific CRE interactions, and demonstrates how non-coding variants affect CM activity in a cell type-specific manner.

The paper identifies 'context-only' transcription factors that contribute to enhancer communication by forming cooperative environments with pioneer factors.

The paper investigates how PRC2 sub-complexes recruit to target genes in mESCs, revealing mutual reinforcement and feedback mechanisms between PRC2.1, PRC2.2, and PRC1.

This study shows that P53 regulates G1-phase progression in ground state ESCs by controlling RB expression, and its inactivation leads to loss of RB and uncontrolled proliferation.