Senthilnath Lakshmanachetty

This study shows that ultrasound-mediated BBB modulation alone does not generate effective CNS immunity, but combining it with systemic immune activation enhances T-cell responses and improves immunotherapy efficacy.

This paper develops a spike-in probe-enhanced scRNA-seq method to track and profile synNotch-CAR-T cells in vivo, revealing tissue-specific activation and transcriptional states.

This study investigates how differential phagocytosis induced by RT or anti-CD47 therapy affects macrophage activation states in gliomas, showing that combination therapy reduces tumor growth and induces distinct macrophage states.

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.