Author

Hiroyuki Kogashi

Chiba UniversityORCID 0000-0002-3855-6309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Kazuma NakataniiD· 2 shared Kazuto KugouiD· 2 shared Yoshinori HasegawaiD· 2 shared Yoshitaka HippoiD· 2 shared Yusuke SuenagaiD· 2 shared Eisaku Furukawa· 1 shared Emiri KitaiD· 1 shared Jason Ching‐Yao LiniD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Kazuma NakataniORCID

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2 papers

Recent·Most cited

Cancer BiologyFrontiers in OncologyPeer-reviewedFeb 8, 2024

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

Kazuma Nakatani, Hiroyuki Kogashi, Takanori Miyamoto…·Yusuke Suenaga

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

8 citations

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJun 2, 2023

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

Yusuke Suenaga, Hiroyuki Kogashi, Kazuma Nakatani…·Yoshitaka Hippo

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

3 citations

mousehuman

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