William Barclay

This study designs sulfonated polymersomes that inhibit multiple viruses by targeting host cell receptors, showing potent in vitro and in vivo antiviral activity.

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

This study shows that the mammalian-adaptive PB2-E627K mutation in H5N1 HPAIV maintains viral fitness in avian hosts, increasing zoonotic risk.

This study examines HA mutations in bovine-origin H5N1 influenza viruses, finding they retain avian receptor binding but show increased HA stability, potentially raising zoonotic risk.

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

This study identifies RBM6 as a host factor that enhances EA H1N1 SIV replication through alternative splicing at the M901 site, with implications for viral adaptation and interspecies transmission.

This study identifies host proteins co-opted by influenza A virus polymerase for transcription or replication using differential interactome screening.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

This study compares host metabolic and signaling responses to SARS-CoV-2 variants, finding that Omicron causes a more restrained response compared to pre-Omicron variants.

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Haemagglutinin of US cattle and goat H5N1 binds only avian-type receptors and fuses at pH 5.9; seven emerging cattle mutations did not switch receptor preference.

The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.

This study investigates enzalutamide's antiviral effects against seasonal coronaviruses and identifies differences in viral-androgen signaling interactions between HCoV-229E and HCoV-OC43.

The paper screens bat samples for coronaviruses, identifies novel strains, and assesses their potential to infect humans.