Jonathan C. Brown

This study designs sulfonated polymersomes that inhibit multiple viruses by targeting host cell receptors, showing potent in vitro and in vivo antiviral activity.

This study identifies host proteins co-opted by influenza A virus polymerase for transcription or replication using differential interactome screening.

This study compares host metabolic and signaling responses to SARS-CoV-2 variants, finding that Omicron causes a more restrained response compared to pre-Omicron variants.

The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.