Thomas P. Peacock

The paper analyzes the spread of H5N1 B3.13 in U.S. dairy cattle using genomic data and movement networks, finding that cattle movement, not birds, drives the outbreak.

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

This study shows that the mammalian-adaptive PB2-E627K mutation in H5N1 HPAIV maintains viral fitness in avian hosts, increasing zoonotic risk.

This study examines HA mutations in bovine-origin H5N1 influenza viruses, finding they retain avian receptor binding but show increased HA stability, potentially raising zoonotic risk.

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

This study identifies RBM6 as a host factor that enhances EA H1N1 SIV replication through alternative splicing at the M901 site, with implications for viral adaptation and interspecies transmission.

The paper introduces Flu Mutation Explorer, a web tool that integrates IAV genomic data with mutation annotations to help interpret host adaptation mutations.

This study compares antigenic profiles of post-infection antisera from pigs and ferrets against human influenza A(H1N1pdm09) viruses, finding similar reactivity but limitations in detecting antigenic drift variants.

This study tracks the emergence and molecular evolution of H5N1 influenza viruses in U.S. dairy cattle, identifying increased mutation rates and positive selection after spillover from birds.

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

This study uses mutational spectra to infer influenza virus transmission routes and adaptive mutations enabling sustained respiratory transmission.

This study examines the host range and antigenicity of bat sarbecoviruses, finding that generalist ACE2 users are more related to SARS-CoV-2 and show broader cross-neutralization.

The study shows cow mammary gland cells can support replication of multiple IAV strains and are susceptible to co-infection with human and avian IAVs, suggesting the udder may act as a site for viral reassortment.

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Haemagglutinin of US cattle and goat H5N1 binds only avian-type receptors and fuses at pH 5.9; seven emerging cattle mutations did not switch receptor preference.

The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

Reanalysis of public environmental metatranscriptomes from the Huanan market links SARS-CoV-2 positivity to one wildlife stall containing raccoon dog, civet and bamboo rat genetic material.

The paper screens bat samples for coronaviruses, identifies novel strains, and assesses their potential to infect humans.

The paper identifies a novel SARS-CoV-2 Delta-Omicron recombinant virus in the United States with a hybrid Spike protein.

This paper identifies a common TMPRSS2 variant that reduces the risk of severe COVID-19 by impairing SARS-CoV-2 entry into cells.