Yuchen He

SheepEpimap combines 516 histone CUT&Tag, ATAC-seq and RNA-seq datasets from 43 sheep tissues to annotate 2.93 million cis-regulatory elements and 145,407 allele-specific variants for trait interpretation.

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

This study investigates the thermogenic potential of naked mole-rat brown adipose tissue and its ability to maintain body temperature in cold, finding that NMRs can initiate non-shivering thermogenesis but cannot sustain it due to heat loss and substrate limitations.

This paper introduces a method to control small GTPase activity using split-GTPases and user-defined chemical inducers, enabling precise temporal regulation of cellular signaling.

This paper introduces a split-protein-based method to directly activate small GTPase signaling in living cells using standardized parts that work across the superfamily.

This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.