Mack B. Reynolds

This study identifies an IL-10/ACOD1 axis that reprograms lipid metabolism in trained macrophages to promote resolution of inflammation.

This study identifies RUNX1 and YY1 as master transcription factors modulating neuronal fate and energy metabolism in Alzheimer's disease using patient-derived induced neurons and post-mortem brain data.

This study uses mass spectrometry and in vivo 13C tracing to show itaconate is rapidly cleared from plasma, excreted in urine, and metabolized in the liver and kidneys.

This study identifies phosphorylation sites in BCL2L13 regulated by AMPK and TBK1, revealing a novel mechanism for mitophagy regulation.

The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

This study shows that Candida albicans activates IRE1 in macrophages through non-canonical mechanisms, enhancing fungicidal activity by promoting phagolysosomal fusion.