Teresa R. O’Meara

This study defines the pan-genome of Candidozyma auris and identifies essential genes, revealing organism-specific biology and potential antifungal targets.

This study shows Candidozyma auris uses transferrin-bound iron for growth and virulence, not heme, and identifies transferrin saturation as a host susceptibility factor.

This study shows that bacterial metabolites alter C. albicans cell wall composition, affecting antifungal resistance and immune recognition.

The paper demonstrates a framework using BRC-Analytics and agentic AI to standardize RNA-seq analysis of fungal pathogens, achieving reproducible results across studies with differing annotations.

This study identifies loss-of-function mutations in RBA1 as a convergent adaptation in C. auris that enhances its ability to adhere, form biofilms, and cause infections.

This study compares the virulence of Candidozyma auris in different growth phases in mice, finding that log phase causes rapid mortality while stationary phase leads to extended survival.

The paper uses structural similarity to identify and design proteasome chaperone proteins in Candida auris, showing conservation of function despite sequence divergence.

This study identifies Als4112 as critical for Candida auris skin colonization and explores collagen coatings to prevent adherence.

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

CryptoCEN, a co-expression network for Cryptococcus neoformans, identifies 13 novel DNA damage repair genes with 100% predictive accuracy.

This study shows that Candida albicans activates IRE1 in macrophages through non-canonical mechanisms, enhancing fungicidal activity by promoting phagolysosomal fusion.