Matthias Nahrendorf

This study shows that silencing Spp1 in TREM2+ cardiac macrophages reduces atrial fibrosis and suppresses AFib in mice, suggesting a new immunotherapy approach.

This study shows that inhibiting monocyte migration via CCR2 deficiency reduces arterial thrombosis and improves thrombolysis in mice.

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

The paper shows that bone marrow stromal cells in HFpEF respond to IFNγ, driving monocyte expansion and fibrosis, which can be mitigated by IFNγ receptor deletion.

This study shows that anti-CD45-ADC clears tissue-resident myeloid cells, enabling efficient replacement with donor cells and reducing atherosclerotic plaque burden.