Sarah Elizabeth Blutt

This study shows that the order of RSV and RV infection in infants determines disease outcome through type III interferon-mediated viral interference.

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

This study identifies D-alanine aminotransferase (Dat) as critical for Staphylococcus aureus colonization of human nasal epithelium, showing its role in D-alanine production and fitness in this environment.

This study shows RSV can infect respiratory epithelium via the basolateral route, targeting basal cells, with RSV/B/BA showing higher basolateral infectivity than RSV/A/ON.

This study shows that Streptococcus pneumoniae precolonization reduces RSV levels and modulates epithelial transcriptional responses to RSV infection more than other nasal bacteria.

This study uses human nasal epithelial organoids to investigate how different bacteria colonize nasal tissue and induce cytokine responses, finding differential effects on chemokines and inflammasome signaling.

This study develops human bladder organoids to model UTIs and phage therapy, showing phage reduces bacterial loads and inflammation during infection.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.