Ying K. Tam

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

This study shows mRNA-LNP vaccines against HBV induce strong immune responses in both preventive and chronic infection models in mice.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

The paper demonstrates that transient mRNA-based growth factor expression in lipid nanoparticles enhances PHH engraftment and liver function in murine liver disease models.

This study identifies distinct roles of nucleoside-modified mRNA and lipid nanoparticles in promoting Tfh cell responses through different mechanisms.

This study investigates how lipid nanoparticles interact with mucus in healthy and cystic fibrosis conditions, identifying factors affecting their diffusivity for improved transmucosal delivery.