Adrian Janiszewski

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.

The paper reconstructs gene regulatory networks in human adult pancreatic cell types and identifies key transcription factors regulating cell identity.

This study shows that autologous micrograft therapy accelerates wound healing by enhancing fibroblast migration through ERK pathway activation and increased matrix metalloproteinase activity.

This study identifies sequential activation of Tet1 and Oct4 during iPSC reprogramming, revealing distinct DNA demethylation waves and epigenetic dynamics critical for generating high-quality iPSCs.

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

This study shows that X-chromosome dosage in mouse iPSCs affects chromatin accessibility, transcriptome, growth, and pluripotency exit, largely independent of DNA methylation.