Jingran Zhang

This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.

This study identifies MAB_2363 as a division-associated protein that contributes to intrinsic resistance and virulence in Mycobacterium abscessus by affecting cell division and antibiotic susceptibility.

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.