V. Siddartha Yerramilli

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

The paper develops MGA scaffolds to enhance fluorescence signals for RNA labeling in live cells, achieving up to 20-fold brighter signals than baseline.

The paper shows that genetic regulation at the population level depends on cell-to-cell variability in regulatory factor concentrations and the 5' UTR of the regulator gene.