Author

Sohini Chakraborti

University of DundeeORCID 0000-0002-4591-2658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Alessio CiulliiD· 2 shared Manon SturbautiD· 2 shared Zoe J. RutteriD· 2 shared Alena KroupovaiD· 1 shared Andre J. WijayaiD· 1 shared Angus D. CowaniD· 1 shared Darren DarreniD· 1 shared David ZollmaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Alessio CiulliORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintDec 22, 2025

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan…·Alessio Ciulli

This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.

1 citation

humanstructural biology

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BiochemistryNature CommunicationsPeer-reviewedOct 15, 2024

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter…·Alessio Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

53 citationstop 2%

protein structureexperimental assay

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